Animal Brains Exhibit no Neurofibrillary Tangles

Autopsied brains of ALS-PD patients exhibit a distinct pattern of neurofibrillary tangles. This characteristic pattern is the outstanding pathological feature of the Guam diseases.

Figure: Molecular structure of BMAA.

In studies in which animals were injected with the amino acid BMAA, neurofibrillary tangles (NFTs) never showed up in the animals' brains. Chemist Peter Nunn used BMAA in clinical trials on rats and found that there was no effect after 70 days.